We build, back, and advise

impact-driven health

tech startups.

based in
San Francisco

Consumer design meets clinical impact.

Pistole Labs is a venture platform that incubates, advises, and invests in health tech startups building consumer-grade products that drive clinical-grade outcomes.

Over the past decade, we've done this work ourselves—at Oura, Calm, and Google X—taking products from zero to tens of millions of lives and hundreds of millions in revenue.

We've co-founded three startups (two exits), worked hands-on with 30+ founders, and built an investment portfolio spanning 20+ companies, including Anthropic, Galileo, and Omada Health.

We partner with a small number of companies each year as a fractional executive or senior advisor—working side-by-side with leadership teams on new venture creation, go-to-market strategy, and enterprise growth.

If you'd like to explore working together, our inbox is always open.

Seed Capital

We invest in early-stage companies where product engagement is the engine for quantifiable health outcomes.

New Ventures

We partner with founders to incubate, launch, and scale new ventures with transformative growth potential.

B2B Growth

We help companies design and scale GTM motions across enterprise sales, partnerships, and B2B2C channels.

Sequoia Capital
Google Ventures
Y Combinator
Andreessen Horowitz
First Round Capital
We're proud founders, advisors, and investors in category-defining health tech companies.
Oura
ŌURA
Wearable biosensor that measures 50+ health biometrics
Calm
Calm
#1 app for sleep, stress, and mindfulness
Big Health
Big Health
Prescription digital therapeutics for insomnia, anxiety, and depression
Galileo Health
Galileo Health
Fully bilingual health platform offering 24/7 virtual-first care
Omada Health
Omada Health
Team-based, integrative care for chronic conditions
Anthropic
Anthropic
Safety-led next generation large language models
Verily
Verily
AI-native data platform purpose-built for precision health
Journey Clinical
Journey Clinical
Practice management software for psychedelic-assisted therapy
Forta Health
Forta Health
AI-driven personalized therapy for autism spectrum disorder
Bryte
Bryte
Multi-sensory, adaptive smart bed sleep system
Koko
Koko
AI-powered suicide identification and prevention
Kindbody
Kindbody
Leading network of tech-enabled fertility clinics
Healthie
Healthie
Full-stack tech infrastructure for virtual-first care
Miga Health
Miga Health
Virtual collaborative care program for cardiometabolic health
Motivo Health
Motivo Health
Virtual clinical supervision for behavioral health providers
Simple Habit
Simple Habit
Bite-sized mindfulness for busy professionals
SpaceX
SpaceX
Reusable rocket technologies to reduce the cost of space access
Bright Minds
Bright Minds
Novel serotonergic therapeutics for psychiatric disorders
We always enjoy connecting with mission-driven founders, potential partners, and fellow investors.

You can reach us via email or LinkedIn.