We build, back, and advise

impact-driven health

tech startups.

based in
San Francisco

Our hypothesis is simple—consumer design drives clinical outcomes.

Pistole Labs incubates, advises, and invests in health tech startups building at the intersection of consumer-grade engagement and clinical-grade outcomes.

Over the past decade, we've done this work ourselves—at Oura, Calm, and Google X—taking products from zero to tens of millions of lives and hundreds of millions in revenue.

We've co-founded three startups (two exits), advised over 30 founders, and built an investment portfolio spanning 20+ companies—including Anthropic, Bright Minds (IPO), and Omada Health (IPO).

We partner with a select number of companies each year as a fractional executive or senior advisor—working side-by-side with leadership teams on new venture creation, go-to-market strategy, and enterprise growth.

If you'd like to explore working together, our inbox is always open.

Seed Capital

We invest in early-stage companies where product engagement is the engine for quantifiable health outcomes.

New Ventures

We partner with founders to develop, launch, and scale 0→1 ventures with transformative growth potential.

B2B Growth

We help companies design and scale GTM motions across enterprise sales, partnerships, and B2B2C channels.

Sequoia Capital
Google Ventures
Y Combinator
Andreessen Horowitz
First Round Capital
We're proud founders, advisors, and investors in category-defining health tech companies.
Oura
ŌURA
Wearable biosensor that measures 50+ health biometrics
Calm
Calm
#1 app for sleep, stress, and mindfulness
Big Health
Big Health
Prescription digital therapeutics for insomnia, anxiety, and depression
Galileo Health
Galileo Health
Fully bilingual health platform offering 24/7 virtual-first care
Omada Health
Omada Health
Team-based, integrative care for chronic conditions
Anthropic
Anthropic
Safety-led next generation large language models
Verily
Verily
AI-native data platform purpose-built for precision health
Journey Clinical
Journey Clinical
Practice management software for psychedelic-assisted therapy
Bryte
Bryte
Multi-sensory, adaptive smart bed sleep system
Forta Health
Forta Health
AI-driven personalized therapy for autism spectrum disorder
Koko
Koko
AI-powered suicide identification and prevention
Kindbody
Kindbody
Leading network of tech-enabled fertility clinics
Motivo Health
Motivo Health
Virtual clinical supervision for behavioral health providers
Healthie
Healthie
Full-stack tech infrastructure for virtual-first care
Empower Sleep
Empower Sleep
In-network virtual sleep medicine clinic and coaching
Miga Health
Miga Health
Collaborative care program for cardiometabolic health
Simple Habit
Simple Habit
Bite-sized mindfulness and meditation sessions
Bright Minds
Bright Minds
Novel serotonergic therapeutics for psychiatric disorders
We always enjoy connecting with health tech founders, potential partners, and fellow investors.

You can reach us via email or LinkedIn.